Clonotypic Features of Rearranged Immunoglobulin Genes Yield Personalized Biomarkers for Minimal Residual Disease Monitoring in Multiple Myeloma
This paper successfully demonstrates the use of the clonal Ig fingerprint in MM patients as a suitable MRD target for MS-MRD analyses. The monoclonal Ig clone signature is unique and harbors multiple MS-suitable clonotypic peptides for each patient with MM. Furthermore, the clonal Ig-rearrangements of both the heavy chain and light chain Ig loci are stable during MM disease progression.